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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36711 | FM19G11 | FM19G11,HIF-1alpha/2alpha Inhibitor | HIF |
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay). | |||
T0692 | Allopurinol | Zyloric,Zyloprim,Lopurin | ROS , Xanthine Oxidase |
Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor. | |||
T6376 | Allopurinol Sodium | Allopurinol sodium salt,Sodium allopurinol | ROS |
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. | |||
T17009 | TC-S 7009 | HIF | |
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene e... | |||
T6804 | Chetomin | Chaetomin,NSC289491,BRN0077366 | Apoptosis , HSP , HIF |
Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations. | |||
T61442 | HIF-1/2α-IN-1 | ||
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea... | |||
TP2046 | TAT-cyclo-CLLFVY | ||
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expressi... | |||
T69966 | Roxadustat-d5 | ||
Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.... |